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Chapter 91. Colorectal Cancer

Student Questions

Which of the following is the main risk factor for the development of colon cancer?

A. Age

B. Familial adenomatosis polyposis (FAP)

C. Chronic NSAID use

D. Gender

Answer: A

Option A: Correct. Age appears to be the biggest risk factor for the development of colorectal cancer with 57% of cases diagnosed in adults older than 65 years of age.

Option B: Incorrect. Familial adenomatosis polyposis (FAP) is a risk factor but not the main risk factor.

Option C: Incorrect. Chronic NSAID use is not a risk factor

Option D: Incorrect. There are more cases diagnosed in males compared to females but it is not the main risk factor.

Which of the following is a common presenting sign and symptom for colon cancer?

A. Infection

B. Low platelet count

C. Abdominal pain

D. Elevated serum creatinine

Answer: C

Option A: Incorrect. Infection is not a common presenting sign or symptom.

Option B: Incorrect. Thrombocytopenia is not a common presenting sign or symptom.

Option C: Correct. Abdominal discomfort is a common symptom upon presentation.

Option D: Incorrect. Elevated serum creatinine is not a common presenting sign.

In which stage of colon cancer has adjuvant chemotherapy been proven to have no clinical benefit?

A. Stage I

B. Stage II

C. Stage III

D. Stage IV

Answer: A

Option A: Correct. There is no benefit in adjuvant chemotherapy in stage I disease.

Option B: Incorrect. Adjuvant chemotherapy may benefit patients with stage II disease with high-risk features.

Option C: Incorrect. Adjuvant chemotherapy does benefit patients with stage III disease and is standard of care.

Option D: Incorrect. Adjuvant chemotherapy has no role in stage IV disease.

Stage II colon cancer with which of the following patient or tumor characteristics would likely benefit from treatment with chemotherapy?

A. Younger patients

B. EGFR-positive tumors

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