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Chapter 30. Multiple Sclerosis

Student Questions

Which of the following medications is preferred for treatment of acute relapses?

A. Interferon β-1a

B. Glatiramer acetate

C. Methylprednisolone

D. Tizanidine

Answer: C

Option A: Incorrect. Interferon β-1a is used to prevent relapses, not treat acute relapses.

Option B: Incorrect. Glatiramer acetate is used to prevent relapses, not treat acute relapses.

Option C: Correct. Methylprednisolone or other corticosteroids are used to treat acute relapses.

Option D: Incorrect. Tizanidine is used to treat the symptom of spasticity, not treat acute relapses.

Which of the following medications may be most helpful for MS-associated fatigue?

A. Carisoprodol

B. Tizanidine

C. Amantadine

D. Dicyclomine

Answer: C

Option A: Incorrect. Carisoprodol is a skeletal muscle relaxant.

Option B: Incorrect. Tizanidine is a central alpha-2-adrenergic agonist used to treat spasticity.

Option C: Correct. Amantadine is indicated for treatment of fatigue related to MS.

Option D: Incorrect. Dicyclomine is a muscarinic antagonist used for bladder spasms and urinary incontinence.

Which of the following toxicities is associated with mitoxantrone therapy?

A. Neuropathy

B. Cardiac

C. Renal

D. Pulmonary

Answer: B

Option A: Incorrect. Neuropathy is not associated with mitoxantrone therapy.

Option B: Correct. Congestive heart failure is associated with mitoxantrone therapy. It increases with cumulative dose. Because of this, the dose is limited to a lifetime dose of 140 mg/m2.

Option C: Incorrect. Renal toxicity is not associated with mitoxantrone therapy.

Option D: Incorrect. Pulmonary toxicity is not associated with mitoxantrone therapy.

When should treatment to prevent MS relapses begin?

A. As soon as possible after diagnosis

B. After the fourth relapse

C. When the patient experiences functional impairment

D. Any time after age 35 years

Answer: A

Option A: Correct. Using MRI data, diagnosis can be made ...

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