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Cancer Chemotherapy and Treatment

Chapter 88. Cancer Chemotherapy and Treatment

Student Questions

Which of the following most correctly describes the pattern of cell growth in tumors according to the Gompertzian growth model?

A. The growth rate of tumor cells decreases steadily as the tumor grows larger.

B. The growth rate of tumor cells increases steadily as the tumor grows larger.

C. The growth rate of tumor cells is constant.

D. The growth rate of tumor cells follows an exponential growth pattern.

Answer: A

Option A: Correct. The highest growth rate usually occurs early in the development of the tumor.

Option B: Incorrect. The highest growth rate usually occurs early in the development of the tumor and with treatment decreases.

Option C: Incorrect. The growth rate is variable with a high-growth phase early and a lower growth rate later.

Option D: Incorrect. The growth rate is log-linear not exponentially.

In the multistep model of carcinogenesis, which of the following stages is reversible and is a target for cancer prevention strategies?

A. Initiation

B. Promotion

C. Transformation

D. Progression

Answer: B

Option A: Incorrect. Initiation is not reversible as this is the step where a cell encounters a carcinogenic substance. Once an encounter occurs then you can reverse the process

Option B: Correct. Promotion occurs after an encounter with a carcinogenic substance and can be reversible.

Option C: Incorrect. Transformation is the step at which the cell becomes malignant and is not a reversible process but can be treatable.

Option D: Incorrect. Progression occurs when tumor spreads. This is not reversible but often treatable to halt further progression.

Individuals homozygous for UGT1A1*28 are at an increased risk of febrile neutropenia and diarrhea and should be considered for upfront dose reduction when receiving which of the following agents?

A. Ifosfamide

B. Cabazitaxel

C. Regorafenib

D. Irinotecan

Answer: D

Option A: Incorrect. Individuals homozygous for UGT1A1*28 are not affected when receiving ifosfamide but another chemotherapy agent

Option B: Incorrect. Individuals homozygous for UGT1A1*28 are not affected when receiving cabazitaxel ...

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