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Anemia

Chapter 66. Anemia

Student Questions

Which regimen provides the recommended daily dose of elemental iron for the treatment of iron related deficiency anemia?

A. Iron fumarate 50 mg, 1 tablet by mouth twice daily

B. Iron gluconate 240 mg, 1 tablet by mouth once daily

C. Iron polysaccharide 125 mg/5 mL, 5 mL by mouth daily

D. Iron sulfate 325 mg, 1 tablet by mouth three times a day

Answer: D

Option A: Incorrect. This is not the correct answer.

Option B: Incorrect. This is not the correct answer.

Option C: Incorrect. This is not the correct answer.

Option D: Correct. The gold standard treatment for IDA is oral iron therapy that provides 150 to 200 mg of elemental iron daily. It is best to give the total daily dose in divided doses to help minimize adverse effects. There are various types of oral iron products available as different salts which each provide differing amounts of elemental iron. Review of Table 66-4 lists the products and the amount of elemental iron provided by each. This regimen provides 195 mg of total daily elemental iron given in divided doses.

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Table 66–4 Oral Iron Products and Elemental Iron Content
Salt Form Brand Name(s) Percent of Elemental Iron Formulation types
Ferrous sulfate

FeroSul

Fer-In-Sol

Slow Fe

~20

Elixir, liquid, solution

Tablet—slow and extended release

Ferrous sulfate, anhydrous N/A ~30 Tablet
Ferrous gluconate Ferate ~12 Tablets
Ferrous fumarate

Ferretts

Ferrimin

Hemocyte

33 Tablets
Polysaccharide–iron complex

Niferex

Ferrex

NovaFerrum

Dose expressed as elemental iron

Liquid

Capsule

The high molecular weight iron product was removed from the market because:

A. It was a less efficacious agent compared to the low molecular weight iron products

B. The method of administration was complex and labor intensive

C. It required special laboratory monitoring on a frequent basis

D. It was associated with high rate of adverse effects, especially anaphylactic reactions

Answer: D

Option A: Incorrect. This is not the correct answer.

Option B: Incorrect. This is not the correct answer.

Option C: Incorrect. This is not the correct answer.

Option D: Correct. Iron dextran was formulated as a high and low molecular weight product. Based on clinical evidence it was noted that the high molecular weight ...

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