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Chapter 95. Acute Leukemia

Which of the following prognostic factors in AML is associated with the highest risk of relapse?

A. Ethnicity

B. Body mass index

C. Age

D. Minimal residual disease

Which of the following agents is most frequently used as prophylaxis for the prevention of fungal infections in AML?

A. Itraconazole

B. Voriconazole

C. Fluconazole

D. Amphotericin B

Which of the two agents are most frequently used for the treatment of induction therapy in AML?

A. Vincristine and asparaginase

B. Doxorubicin and cyclophosphamide

C. Cytarabine and daunorubicin

D. Methotrexate and vincristine

The single strongest prognostic factor in ALL is:

A. Age

B. Initial white count

C. Presence of central nervous system leukemia (CNS3)

D. Early treatment response as assessed by minimal residual disease(MRD) at end of induction

The ALL treatment modality that is most associated with later development of secondary acute myeloid leukemia with balanced translocations is:

A. Alkylating agents

B. High dose methotrexate

C. Clofarabine

D. Epipodophyllotoxins

Which of the following features excludes a diagnosis of B-cell precursor ALL?

A. Presence of T-cell receptor gene rearrangements

B. Mediastinal mass

C. WBC count > 500,000/microliter

D. Expression of cytoplasmic CD3

Which of the following translocation is seen in Philadelphia chromosome positive (Ph+ pre B-cell ALL) ?

A. t(9;22)(q34;q11)

B. t(1;19)(q23;p13)

C. t(11;14)(p13;q11.2)

D. t(8;22)(q24;q11)

Which of the following prognostic factors is most likely associated with the risk of relapse induction therapy for acute lymphocytic ...

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