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Chapter 91. Colorectal Cancer

Which of the following is the main risk factor for the development of colon cancer?

A. Age

B. Familial adenomatosis polyposis (FAP)

C. Family history

D. Gender

E. Diabetes

Which of the following is a common presenting sign and symptom for colon cancer?

A. Infection

B. High white blood cell count

C. Change in bowel habits

D. Shortness of breath

E. Elevated serum creatinine

In which stage of colon cancer has adjuvant chemotherapy been proven to have no clinical benefit?

A. Stage I

B. Stage II

C. Stage III

D. Stage IV

Stage II colon cancer with which of the following patient or tumor characteristics would likely benefit from treatment with chemotherapy?

A. Younger patients

B. EGFR-positive tumors

C. Patient presents with bowel perforation

D. KRAS mutant positive tumors

E. Patient presents with a T3 lesion

The preferred treatment option for a patient with stage III colon cancer is:

A. Combined chemotherapy and radiation followed by complete surgical resection

B. Chemotherapy followed by complete surgical resection

C. Complete surgical resection followed by adjuvant chemotherapy

D. Curative radiation followed by adjuvant chemotherapy

E. Complete surgical resection with no adjuvant therapy

A68-year-old man diagnosed with stage IV colon cancer (positive for KRAS mutation) is scheduled to receive chemotherapy consisting of the FOLFOX regimen. Which of the following statements regarding his treatment regimen is correct?

A. The bolus schedule of 5- fluorouracil (FU) is preferred because it is associated with a higher response rates compared with infusional 5-FU.

B. EGFR inhibitors, such as cetuximab, should be added to the FOLFOX regimen.


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