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Chapter 58. Osteoarthritis

Which one of the following is characteristic of osteoarthritis (OA)?

A. Unilateral joint pain upon waking

B. Joint stiffness in the morning lasting 45 minutes

C. Elevated C-reactive protein (CRP) level

D. Elevated erythrocyte sedimentation rate (ESR)

E. All of the above

All of the following are considered risk factors for OA except:

A. Heavy physical activity

B. Age

C. Obesity

D. Ethnicity

E. Joint trauma

Which one of the following is the most appropriate treatment approach in a patient at risk for developing OA?

A. Promote lifestyle changes targeted at risk factors for OA

B. Initiate tramadol 50 mg every 4 to 6 hours as needed

C. Initiate ibuprofen 200 mg every 6 hours as needed

D. Initiate acetaminophen 325 mg every 4 to 6 hours as needed, and promote lifestyle changes targeted at risk factors for OA

E. Initiate ibuprofen 200 mg every 6 hours as needed, and promote lifestyle changes targeted at risk factors for OA

Therapy with celecoxib, rather than a non-selective NSAID, would be most appropriate for which of the following patients?

A. 58-year-old woman with metabolic syndrome and gastroesophageal reflux disease

B. 69-year-old man with a history of Helicobacter pylori peptic ulcer disease

C. 53-year-old woman with a strong family history of myocardial infarction and previous GI upset with ibuprofen use

D. 47-year-old man with a history of GI bleed from previous indomethacin use

E. 70-year-old woman with chronic renal insufficiency who takes low-dose aspirin for cardioprotection

Treatment with naproxen monotherapy, rather than another non-selective NSAID, would be most appropriate for which of the following patients?

A. 49-year-old woman with metabolic syndrome and history of MI

B. 70-year-old man with a history of Helicobacter pylori peptic ulcer disease

C. 58-year-old man with a strong family history of myocardial ...

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