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Pharmacotherapy Principles and Practice, 4e

Chapter 19: Inflammatory Bowel Disease

Brian A. Hemstreet

Chapter 19. Inflammatory Bowel Disease

Which mesalamine formulation would be most appropriate for a patient with active ulcerative colitis (UC) who has extensive disease?

A. Intravenous solution

B. Delayed-release capsule

C. Enema

D. Suppository

Which medication is delivered via intravenous infusion?

A. Budesonide

B. Infliximab

C. Balsalazide

D. Methotrexate

Prior to initiating therapy with azathioprine, patients should be evaluated for activity of which enzyme?

A. Thiopurine methyltransferase

B. Azathioprine dehydrogenase

C. Dihydrofolate reductase

D. Alanine aminotransferase

Loperamide should be avoided in patients with active UC due to its ability to induce which one of the following complications?

A. Toxic megacolon

B. Intestinal stricture

C. Fistula formation

D. Pancreatitis

Probiotics may be most helpful in patients with IBD who have:

A. Pouchitis

B. Fistulae

C. Proctitis

D. Arthritis

Which one of the following medications would be contraindicated in a pregnant patient with CD?

A. Sulfasalazine

B. Budesonide

C. Infliximab

D. Methotrexate

Which one of the following disorders is a possible extraintestinal manifestation of inflammatory bowel disease?

A. Erythema nodosum

B. Migraine headaches

C. Asthma

D. Sinusitis

The mechanism of action of vedolizumab can best be characterized as:

A. TNF-α inhibition

B. Purine antagonism

C. Folate antagonism

D. Leukocyte adhesion inhibition

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