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Chapter 95. Acute Leukemia

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Which of the following prognostic factors in AML is associated with the highest risk of relapse?

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A. Ethnicity

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B. Body mass index

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C. Age

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D. Minimal residual disease

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Which of the following agents is most frequently used as prophylaxis for the prevention of fungal infections in AML?

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A. Itraconazole

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B. Voriconazole

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C. Fluconazole

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D. Amphotericin B

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Which of the two agents are most frequently used for the treatment of induction therapy in AML?

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A. Vincristine and asparaginase

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B. Doxorubicin and cyclophosphamide

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C. Cytarabine and daunorubicin

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D. Methotrexate and vincristine

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The single strongest prognostic factor in ALL is:

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A. Age

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B. Initial white count

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C. Presence of central nervous system leukemia (CNS3)

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D. Early treatment response as assessed by minimal residual disease(MRD) at end of induction

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The ALL treatment modality that is most associated with later development of secondary acute myeloid leukemia with balanced translocations is:

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A. Alkylating agents

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B. High dose methotrexate

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C. Clofarabine

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D. Epipodophyllotoxins

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Which of the following features excludes a diagnosis of B-cell precursor ALL?

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A. Presence of T-cell receptor gene rearrangements

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B. Mediastinal mass

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C. WBC count > 500,000/microliter

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D. Expression of cytoplasmic CD3

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Which of the following translocation is seen in Philadelphia chromosome positive (Ph+ pre B-cell ALL) ?

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A. t(9;22)(q34;q11)

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B. t(1;19)(q23;p13)

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C. t(11;14)(p13;q11.2)

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D. t(8;22)(q24;q11)

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Which of the following prognostic factors is most likely associated with the risk of relapse induction therapy for acute lymphocytic ...

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