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Chapter 93. Skin Cancer

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All of the following are risk factors for developing skin cancer except:

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A. Ability to tan easily

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B. Immunosuppression

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C. Aging

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D. History of squamous cell carcinoma

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E. Family history of melanoma

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Which of the follow is not a proper strategy to minimizing exposure to UV rays?

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A. Avoid sunlight when it is most intense during the day

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B. Use sunscreen that is at least SPF 30

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C. Be cautious of sun exposure when surrounded by sand, snow, and water

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D. Application of sunscreen twice a day will provide coverage for the entire day at the beach

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E. The use of hats and tightly woven clothing

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Which of the following DOES NOT match the drug’s mechanism of action?

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A. IL-2 stimulates B and T cells

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B. Trametinib is a MEK kinase inhibitor

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C. Dabrafenib is a BRAF kinase inhibitor

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D. Pembrolizumab inhibits PD-1L of tumor cells

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E. Ipilimumab enhances T-cell activation and proliferation through CTLA-4

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A 35-year-old woman diagnosed with stage IIB melanoma underwent surgical excision of the tumor with a 2-cm margin and a complete lymphadenopathy. Which of the following would be an appropriate adjuvant therapy for this patient?

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A. IL-2

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B. Pegylated IFN

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C. IFN

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D. Dacarbazine

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E. Ipilimumab

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A 35-year-old woman is diagnosed with unresectable stage IIIC melanoma, and the decision was made to start her on dabrafenib. Six weeks into her therapy, it was noted on routine checkup that this patient had developed new lesions on her legs, and further evaluation confirmed that it is squamous cell carcinoma. What is the recommendation for the management of this patient’s therapy now?

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A. Reduce the dose of dabrafenib

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B. Switch to IFN

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C. Continue dabrafenib

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D. Switch to ipilimumab

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