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Chapter 67. Coagulation and Platelet Disorders

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Extrinsic pathway of anticoagulation involves:

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A. Factor XII

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B. Factor VII

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C. Factor IX

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D. Factor XI

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Which of the following statements is true?

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A. Each unit of factor (F) VIII replacement administered per kilogram of body weight raises the plasma FVIII level 1% (0.01 IU/mL [10 IU/L]).

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B. Each unit of FVIII replacement administered per kilogram of body weight raises the plasma FVIII level 2% (0.02 IU/mL [20 IU/L]).

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C. Each unit of FIX replacement administered per kilogram of body weight yields a 0.5% rise in plasma (0.005 IU/mL [5 IU/L]) FIX level.

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D. Each unit of FIX replacement administered per kilogram of body weight yields a 2% rise in plasma (0.02 IU/mL [20 IU/L]) FIX level.

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E. Each unit of FIX replacement administered per kilogram of body weight yields a 3% rise in plasma (0.03 IU/mL [30 IU/L]) FIX level.

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To increase the FVIII level from 0% to 80% in a 50-kg hemophiliac, _____ units of FVIII should be administered.

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A. 500

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B. 3000

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C. 4000

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D. 1600

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E. 2000

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Which of the following is the medication of choice to control mild joint pain associated with joint destruction in patients with hemophilia?

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A. Ibuprofen

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B. Acetaminophen

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C. Oxycodone

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D. Naproxen

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E. Aminocaproic acid

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Which of the following is the best approach to treating a nonbleeding 60-kg hemophilia patient with 3 BU/mL (3000 BU/L) of factor VIII inhibitor?

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A. 7200 mcg of recombinant factor VIIa IV every 2 hours

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B. 4500 units of aPCC IV twice daily

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C. Immune tolerance induction, factor VIII replacement per levels

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D. 6000 porcine units of recombinant porcine factor VIII IV daily

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E. 6000 units of Advate IV twice daily

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Which ...

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