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Chapter 58. Osteoarthritis

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Which one of the following is characteristic of osteoarthritis (OA)?

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A. Unilateral joint pain upon waking

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B. Joint stiffness in the morning lasting 45 minutes

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C. Elevated C-reactive protein (CRP) level

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D. Elevated erythrocyte sedimentation rate (ESR)

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E. All of the above

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All of the following are considered risk factors for OA except:

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A. Heavy physical activity

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B. Age

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C. Obesity

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D. Ethnicity

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E. Joint trauma

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Which one of the following is the most appropriate treatment approach in a patient at risk for developing OA?

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A. Promote lifestyle changes targeted at risk factors for OA

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B. Initiate tramadol 50 mg every 4 to 6 hours as needed

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C. Initiate ibuprofen 200 mg every 6 hours as needed

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D. Initiate acetaminophen 325 mg every 4 to 6 hours as needed, and promote lifestyle changes targeted at risk factors for OA

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E. Initiate ibuprofen 200 mg every 6 hours as needed, and promote lifestyle changes targeted at risk factors for OA

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Therapy with celecoxib, rather than a non-selective NSAID, would be most appropriate for which of the following patients?

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A. 58-year-old woman with metabolic syndrome and gastroesophageal reflux disease

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B. 69-year-old man with a history of Helicobacter pylori peptic ulcer disease

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C. 53-year-old woman with a strong family history of myocardial infarction and previous GI upset with ibuprofen use

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D. 47-year-old man with a history of GI bleed from previous indomethacin use

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E. 70-year-old woman with chronic renal insufficiency who takes low-dose aspirin for cardioprotection

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Treatment with naproxen monotherapy, rather than another non-selective NSAID, would be most appropriate for which of the following patients?

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A. 49-year-old woman with metabolic syndrome and history of MI

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B. 70-year-old man with a history of Helicobacter pylori peptic ulcer disease

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C. 58-year-old man with a strong family history of myocardial ...

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