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Chapter 57. Rheumatoid Arthritis

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Which of the following treatment goals should be considered in a patient newly diagnosed with systemic JIA?

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A. Control of hypertension

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B. Maintain normal growth

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C. Evaluate for osteoporosis risk

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D. Protect joint function by limiting activity

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E. Initiate treatment for uveitis

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A 42-year-old woman presents to your local community pharmacy with complaints of increasing joint pain. She states that her primary care physician is still trying to determine whether the diagnosis is osteoarthritis (OA) or rheumatoid arthritis (RA). While at the pharmacy to fill a new prescription for celecoxib, she asks you if she should be concerned about rheumatoid arthritis because she knows very little about it. In addition to joint pain and swelling, you describe which one of the following as being associated with rheumatoid arthritis?

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A. Asthma

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B. Colon cancer

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C. Osteodystrophy

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D. Renal insufficiency

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E. Cardiovascular disease

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Janus kinases may influence the pathogenesis of RA by:

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A. Releasing cytokines

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B. Releasing antibodies

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C. Presenting antigens to B lymphocytes

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D. Enhancing cell signaling

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E. Binding CD28 receptors to antigen-presenting cells

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Tocilizumab is most appropriate in which one of the following patients?

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A. A 36-year-old woman diagnosed today with mild rheumatoid factor-negative RA

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B. A 51-year-old man with a 2-year history of RF-negative RA and an inadequate response to methotrexate monotherapy and methotrexate/abatacept combination therapy

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C. A 65-year-old man with a 10-year history of RF-positive RA and a fear of needles/injections

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D. A 42-year-old woman with a 6-year history of RF-positive RA and an inadequate response to methotrexate/etanercept and methotrexate/rituximab combination therapy

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E. A 4-year-old boy with juvenile idiopathic arthritis (JIA) and an inadequate response to anakinra

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TP is a 66-year-old woman with a history of RF-positive RA for 10 years of moderate severity with features of poor prognosis, COPD for 3 years, and heart failure for 2 years. She is a smoker and drinks two glasses of wine weekly. She does not ...

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