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Chapter 54. Allergic and Pseudoallergic Drug Reactions

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Of all adverse drug reactions reported in hospitals, the percentage of these that are allergic or immunologic is:

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A. 33%

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B. 50% to 60%

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C. 5% to 10%

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D. 1% to 2%

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E. > 95%

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Fifteen minutes after the start of a piperacillin/tazobactam infusion, the patient develops severe itching and difficulty breathing. What type of Gell and Coombs reaction is occurring?

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A. Type I

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B. Type II

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C. Type III

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D. Type IVa

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E. Type IVb

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A site of drug metabolism that might explain why skin reactions occur with a variety of different drugs is:

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A. Skin keratinocytes

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B. The kidney

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C. Skin epidermocytes

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D. The liver

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E. The lungs

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What type(s) of Gell and Coombs reactions can penicillins cause?

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A. Types I and II only

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B. Types II and III only

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C. Types I and III only

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D. Type I only

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E. Types I, II, III, and IV

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Pseudoallergic drug reactions differ from allergic reactions in that they:

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A. Are based on the structure of the drug

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B. Involve the activation of the patient’s immune system

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C. Represent common biological functions such as direct histamine release

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D. Require the drug to be bound to a protein

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E. Involve T-cell activation

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Of patients claiming to have penicillin allergies, what percentage will have a negative penicillin skin test?

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A. 5%

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B. 33%

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C. 50%

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D. 75%

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E. 90%

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Cross-allergenicity between ...

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