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Chapter 38. Major Depressive Disorder

Which of the following SSRIs requires up to a 5-week washout period because of the long half-life of its potent active metabolite?

A. Escitalopram

B. Fluvoxamine

C. Fluoxetine

D. Sertraline

Which of the following symptoms is most likely to improve within approximately 1 week of starting treatment?

A. Depressed mood

B. Suicidal thoughts

C. Anhedonia

D. Sleep

Of the following combinations of medications, which one would you want to avoid?

A. Fluoxetine-lithium

B. Fluoxetine-phenelzine

C. Citalopram-valproic acid

D. Citalopram-aripiprazole

A 26-year-old man with a history of depression has been taking sertraline 200 mg/day for 12 weeks with no response. The patient has no other complications. The physician asks for your recommendation. The most reasonable recommendation would be to:

A. Increase sertraline

B. Add fluoxetine

C. Switch to amitriptyline

D. Change to venlafaxine

E. Decrease sertraline

Which of the following is a dangerous combination?

A. MAOI-lorazepam

B. MAOI-acetaminophen

C. MAOI-meperidine

D. MAOI-ziprasidone

A 23-year-old married white woman comes to the outpatient psychiatric clinic complaining of decreased sleep, decreased appetite, decreased concentration, depressed mood, thoughts of death, and lack of interest in activities for 6 weeks’ duration. She has no history of psychiatric illness and takes no medications except for Ortho-Tri Cyclen Lo daily. Based upon the patients symptoms, choose the best medication to treat this patient.

A. Nefazodone 100 mg po twice daily

B. Paroxetine 20 mg po daily

C. St. John’s wort 300 mg po three times daily

D. Amitriptyline 25 mg at bedtime

A 36-year-old man is admitted to the hospital for a severe methicillin-resistant Staphylococcus aureus diabetic foot ...

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