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Chapter 38. Major Depressive Disorder

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Which of the following SSRIs requires up to a 5-week washout period because of the long half-life of its potent active metabolite?

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A. Escitalopram

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B. Fluvoxamine

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C. Fluoxetine

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D. Sertraline

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Which of the following symptoms is most likely to improve within approximately 1 week of starting treatment?

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A. Depressed mood

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B. Suicidal thoughts

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C. Anhedonia

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D. Sleep

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Of the following combinations of medications, which one would you want to avoid?

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A. Fluoxetine-lithium

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B. Fluoxetine-phenelzine

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C. Citalopram-valproic acid

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D. Citalopram-aripiprazole

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A 26-year-old man with a history of depression has been taking sertraline 200 mg/day for 12 weeks with no response. The patient has no other complications. The physician asks for your recommendation. The most reasonable recommendation would be to:

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A. Increase sertraline

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B. Add fluoxetine

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C. Switch to amitriptyline

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D. Change to venlafaxine

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E. Decrease sertraline

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Which of the following is a dangerous combination?

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A. MAOI-lorazepam

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B. MAOI-acetaminophen

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C. MAOI-meperidine

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D. MAOI-ziprasidone

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A 23-year-old married white woman comes to the outpatient psychiatric clinic complaining of decreased sleep, decreased appetite, decreased concentration, depressed mood, thoughts of death, and lack of interest in activities for 6 weeks’ duration. She has no history of psychiatric illness and takes no medications except for Ortho-Tri Cyclen Lo daily. Based upon the patients symptoms, choose the best medication to treat this patient.

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A. Nefazodone 100 mg po twice daily

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B. Paroxetine 20 mg po daily

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C. St. John’s wort 300 mg po three times daily

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D. Amitriptyline 25 mg at bedtime

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A 36-year-old man is admitted to the hospital for a severe methicillin-resistant Staphylococcus aureus diabetic foot ...

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