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Chapter 32. Status Epilepticus

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A 46-year-old man is brought into the emergency department after having convulsions for approximately 10 minutes. What is the best choice for an initial medication for this patient?

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A. propofol

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B. phenytoin

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C. diazepam

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D. phenobarbital

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E. topiramate

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A patient is admitted to the emergency department and diagnosed with status epilepticus. He has a blood pressure of 90/65 and a heart rate of 120 beats/min. Which of the following combinations of agents will have the least effects on this patient’s cardiorespiratory system?

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A. lorazepam and phenytoin

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B. midazolam and valproate sodium

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C. diazepam and fosphenytoin

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D. midazolam and phenobarbital

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E. lorazepam and propofol

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Which of the following is a sign of prolonged generalized convulsive status epilepticus?

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A. hypertension

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B. incontinence

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C. sweating

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D. fever

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E. rhabdomyolysis

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Which of the following receptor activity changes may occur during status epilepticus?

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A. A decrease in GABA receptor activity and an increase in NMDA receptor activity

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B. An increase GABA receptor activity and an increase in NMDA receptor activity

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C. A decrease in GABA receptor activity and a decrease in NMDA receptor activity

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D. An increase in GABA receptor activity and a decrease in NMDA receptor activity

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E. None of the above

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All of the following drugs used in the treatment of status epilepticus contain considerable amounts of propylene glycol except?

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A. diazepam

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B. fosphenytoin

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C. lorazepam

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D. phenytoin

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E. Both B and D

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A patient is receiving an intravenous loading dose of phenytoin 1000 mg as therapy for status epilepticus. Over what minimal time period should this dose be infused?

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A. 5 minutes

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