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Chapter 18. Peptic Ulcer Disease

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Which of the following is not a common cause of peptic ulcer disease (PUD)?

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A. Chronic alcohol ingestion

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B. Nonsteroidal antiinflammatory drugs (NSAIDs)

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C. Stress-related mucosal damage

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D. Helicobacter pylori infection

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E. All of the above are common causes of PUD

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Which of the following is a complication of PUD?

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A. GI bleeding

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B. Perforation

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C. Obstruction

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D. All of the above

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E. None of the above

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Which of the following is an indication for stress ulcer prophylaxis (SUP) in critically ill patients according to the 1999 American Society of Health-System Pharmacists (ASHP) published guidelines?

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A. Mechanical ventilation for longer than 48 hours

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B. Patients admitted to telemetry for heart failure

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C. Platelet count greater than 50,000/mm3 (50 × 109/L) but less than 150,000/mm3(150 × 109/L)

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D. Thermal injuries to more than 15% of body surface area

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E. Admission to ICU on enteral feedings

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Which of the following is an important mechanism of prostaglandin mucosal protection?

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A. Stimulation of both mucus and phospholipid production

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B. Promotion of bicarbonate secretion

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C. Increased mucosal cell turnover

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D. All of the above

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E. None of the above

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A 65-year-old woman presents with new onset epigastric pain, recent 10-pound (4.5kg) weight loss, and anemia. What diagnostic test should this patient undergo?

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A. Urea breath test

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B. Stool antigen testing for H. pylori

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C. Esophagogastroduodenoscopy (EGD)

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D. H. pylori serology testing

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E. Manometry

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A prophylactic medication regimen to prevent NSAID-induced ulcers would not be recommended in:

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A. A 65-year-old patient on long-term NSAID therapy for osteoarthritis

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