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Chapter 18. Peptic Ulcer Disease

Which of the following is not a common cause of peptic ulcer disease (PUD)?

A. Chronic alcohol ingestion

B. Nonsteroidal antiinflammatory drugs (NSAIDs)

C. Stress-related mucosal damage

D. Helicobacter pylori infection

E. All of the above are common causes of PUD

Which of the following is a complication of PUD?

A. GI bleeding

B. Perforation

C. Obstruction

D. All of the above

E. None of the above

Which of the following is an indication for stress ulcer prophylaxis (SUP) in critically ill patients according to the 1999 American Society of Health-System Pharmacists (ASHP) published guidelines?

A. Mechanical ventilation for longer than 48 hours

B. Patients admitted to telemetry for heart failure

C. Platelet count greater than 50,000/mm3 (50 × 109/L) but less than 150,000/mm3(150 × 109/L)

D. Thermal injuries to more than 15% of body surface area

E. Admission to ICU on enteral feedings

Which of the following is an important mechanism of prostaglandin mucosal protection?

A. Stimulation of both mucus and phospholipid production

B. Promotion of bicarbonate secretion

C. Increased mucosal cell turnover

D. All of the above

E. None of the above

A 65-year-old woman presents with new onset epigastric pain, recent 10-pound (4.5kg) weight loss, and anemia. What diagnostic test should this patient undergo?

A. Urea breath test

B. Stool antigen testing for H. pylori

C. Esophagogastroduodenoscopy (EGD)

D. H. pylori serology testing

E. Manometry

A prophylactic medication regimen to prevent NSAID-induced ulcers would not be recommended in:

A. A 65-year-old patient on long-term NSAID therapy for osteoarthritis


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