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Chapter 3. Pediatrics

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AJ is a 14-day-old premature male infant, born at 30-week GA, started on ampicillin and gentamicin for neonatal sepsis. Which pharmacokinetic parameter affects the patient’s dosing frequency of gentamicin?

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A. Absorption

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B. Protein binding

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C. Metabolism—Phase I reactions

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D. Metabolism—Phase II reactions

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E. Elimination half-life

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Which is an appropriate maintenance fluid requirement for a 4-year-old boy with a weight of 40 pounds?

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A. ~1400 mL/day

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B. ~1600 mL/day

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C. ~1800 mL/day

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D. ~2000 mL/day

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E. ~2200 mL/day

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MM is a 6-month-old male infant who was born at 34-week GA. You are asked to evaluate his renal function in preparation for starting intravenous antibiotics. Which method for assessment is most appropriate?

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A. “Bedside” Schwartz equation

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B. Cockcroft–Gault equation

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C. Schwartz (original) equation

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D. Modification of diet in renal disease (MDRD) equation

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E. Urine output alone

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PG, a 1-week-old, 2.5-kg girl born at 30-week GA, is to be started on gentamicin for suspected neonatal sepsis. Which of the following is true regarding PG’s apparent volume of distribution (Vd) in milliliters per kilogram for gentamicin compared with adults and children with normal renal function?

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A. Vd will be less than those used in adults and children.

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B. Vd will be greater than those used in adults and children.

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C. Vd will be less than those used in adults but similar to children.

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D. Vd will be greater than those used in adults but less than in children.

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E. Vd will be the same as adults and children.

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NC is a 5-year-old boy who is to start carbamazepine, an antiepileptic medication, for seizure disorder. Which pharmacokinetic parameter affects his daily dose requirement of carbamazepine, by body weight?

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A. Absorption

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B. Distribution

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C. Metabolism—Phase I reactions

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