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Allergic and Pseudoallergic Drug Reactions

Chapter 54. Allergic and Pseudoallergic Drug Reactions

Of all adverse drug reactions reported in hospitals, the percentage of these that are allergic or immunologic is:

A. 33%

B. 50% to 60%

C. 5% to 10%

D. 1% to 2%

E. > 95%

Fifteen minutes after the start of a piperacillin/tazobactam infusion, the patient develops severe itching and difficulty breathing. What type of Gell and Coombs reaction is occurring?

A. Type I

B. Type II

C. Type III

D. Type IVa

E. Type IVb

A site of drug metabolism that might explain why skin reactions occur with a variety of different drugs is:

A. Skin keratinocytes

B. The kidney

C. Skin epidermocytes

D. The liver

E. The lungs

What type(s) of Gell and Coombs reactions can penicillins cause?

A. Types I and II only

B. Types II and III only

C. Types I and III only

D. Type I only

E. Types I, II, III, and IV

Pseudoallergic drug reactions differ from allergic reactions in that they:

A. Are based on the structure of the drug

B. Involve the activation of the patient’s immune system

C. Represent common biological functions such as direct histamine release

D. Require the drug to be bound to a protein

E. Involve T-cell activation

Of patients claiming to have penicillin allergies, what percentage will have a negative penicillin skin test?

A. 5%

B. 33%

C. 50%

D. 75%

E. 90%


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