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PHARMACOTHERAPY PRINCIPLES AND PRACTICE CARE PLANS & CASES

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LEARNING OBJECTIVES

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LEARNING OBJECTIVES

Upon completion of the chapter, the reader will be able to:

  1. List the most common etiologies of decreased intravascular volume in hypovolemic shock patients.

  2. Describe the major hemodynamic and metabolic abnormalities that occur in patients with hypovolemic shock.

  3. Describe the clinical presentation including signs, symptoms, and laboratory test measurements for the typical hypovolemic shock patient.

  4. Prepare a treatment plan with clearly defined outcome criteria for a hypovolemic shock patient that includes both fluid management and pharmacologic therapy.

  5. Compare and contrast relative advantages and disadvantages of crystalloids, colloids, and blood products in the treatment of hypovolemic shock.

  6. Formulate a stepwise monitoring strategy for a hypovolemic shock patient.

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INTRODUCTION

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The primary function of the circulatory system is to supply oxygen and vital metabolic compounds to cells throughout the body, as well as removal of metabolic waste products. Circulatory shock is a life-threatening condition whereby this principal function is compromised resulting in inadequate cellular oxygen utilization.1,2 When circulatory shock is caused by a severe loss of blood volume or body water, it is called hypovolemic shock. KEY CONCEPT Regardless of etiology, the most distinctive clinical manifestations of hypovolemic shock are arterial hypotension, clinical signs of hypoperfusion, and metabolic acidosis.2 Metabolic acidosis is a consequence of an accumulation of lactic acid resulting from tissue hypoxia and anaerobic metabolism. If the decrease in arterial blood pressure (BP) is severe and protracted, such hypotension will inevitably lead to severe hypoperfusion and organ dysfunction. Rapid and effective restoration of circulatory homeostasis using fluids, pharmacologic agents, and/or blood products is imperative to prevent complications of untreated shock and ultimately death.

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ETIOLOGY AND EPIDEMIOLOGY

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Practitioners must have a good understanding of cardiovascular physiology to diagnose, treat, and monitor circulatory problems in critically ill patients. The interrelationships among the major hemodynamic variables are depicted in Figure 13–1.3 These variables include arterial BP, cardiac output (CO), systemic vascular resistance (SVR), heart rate (HR), stroke volume (SV), left ventricular size, afterload, myocardial contractility, and preload. Although an oversimplification, Figure 13–1 is beneficial in conceptualizing where the major abnormalities occur in patients with circulatory shock as well as predicting the body’s compensatory responses.

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FIGURE 13–1.

Hemodynamic relationships among key cardiovascular parameters (A). Solid lines represent a direct relationship; the broken line represents an inverse relationship. In (B), the alterations typically observed in hypovolemic shock are highlighted with arrows depicting the likely direction of the alteration. (Panel A from Braunwald E. Regulation of the circulation. I. N Engl J Med. 1974;290:1124–1129, with permission.)

Graphic Jump Location
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Hypovolemic shock is caused by a loss of intravascular volume either by hemorrhage or fluid loss (eg, dehydration). ...

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